Product Name :
Phospho-Cytosolic Phospholipase A2 (S505) Recombinant Rabbit Monoclonal Antibody [PSH07-56]
Predicted band size :
85 kDa
Observed band size :
100 kDa
Synonyms:
Calcium dependent phospholipid binding protein antibody CPLA 2 antibody cPLA2 alpha antibody cPLA2 antibody Cytosolic phospholipase A2 antibody Cytosolic phospholipase A2 group IVA antibody Lysophospholipase antibody MGC126350 antibody PA24A_HUMAN antibody Phosphatidylcholine 2 acylhydrolase antibody 展开
Function :
Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene.1608495-27-7 manufacturer This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic phospho-peptide corresponding to residues surrounding Ser505 of human cPLA2 aa 491-540.
Species reactivity:
Human, Mouse
Verify application:
WB, Dot Blot
Coupling :
unconjugated
Clone number:
PSH07-56
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.1450835-21-8 custom synthesis Aliquot store at -20℃.PMID:33550928 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 85 kDa
Positive control :
HeLa cell lysate, RAW264.7 cell lysates.