Product Name :
Uromucoid Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
ADMCKD2 antibody FJHN antibody HNFJ antibody HNFJ1 antibody MCKD2 antibody medullary cystic kidney disease 2 (autosomal dominant) antibody Tamm Horsfall glycoprotein antibody Tamm Horsfall urinary glycoprotein antibody Tamm-Horsfall urinary glycoprotein antibody THGP antibody 展开
Function :
Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle’s loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial (By similarity).Formula of 6-Bromo-4(1H)-cinnolinone Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from mouse MCKD2 351-450/642
Species reactivity:
Human, Mouse, Rat, Cow
Verify application:
ELISA, IHC-P, FC, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.387859-70-3 web Avoid repeated freeze/thaw cycles.PMID:33611929 The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
1:5000-10000
Molecular weight :
61/65 KDa
Positive control :
Mouse kidney tissue.