The bone-resorptive effects. NOTCH inhibition increases osteoclastogenesis (44), and myeloid-specific deletion of
The bone-resorptive effects. NOTCH inhibition increases osteoclastogenesis (44), and myeloid-specific deletion of RBPj enhances TNF-induced osteoclast formation (41). Even so, NOTCH activation has been previously reported in synovial samples from…