Product Name :
1,2-Dichloropropane (CAS 78-87-5)
Synonym :
Application :
1,2-Dichloropropane is A byproduct in the production of epichlorohydrin
CAS:
78-87-5
Purity:
Molecular Weight:
112.99
Formula :
C3H6Cl2
Physical state:
Liquid
solubility :
Soluble in water (2.7 mg/ml at 20° C), ethyl acetate, chloroform, ether, and alcohol.
Shipping Condition :
Store at room temperature
Melting point:
-100° C (lit.N-Fmoc-N’-methyl-L-asparagine web )
SMILES:
CC(Cl)CCl
References:
:Dehalogenimonas spp. can Reductively Dehalogenate High Concentrations of 1,2-Dichloroethane, 1,2-Dichloropropane, and 1,1,2-Trichloroethane. | Maness, AD., et al. 2012. AMB Express. 2: 54. PMID: 23046725Assessment of the genotoxicity of 1,2-dichloropropane and dichloromethane after individual and co-exposure by inhalation in mice. | Suzuki, T., et al. 2014. J Occup Health. 56: 205-14. PMID: 24739373Photoinitiators enhanced 1,2-dichloropropane-induced cytotoxicity in human normal embryonic lung fibroblasts cells in vitro.926659-01-0 Chemscene | Kawasaki, Y.PMID:33742107 , et al. 2015. Environ Sci Pollut Res Int. 22: 4763-70. PMID: 25501643Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters. | Gi, M., et al. 2015. J Toxicol Sci. 40: 647-56. PMID: 26354381Relationship between cumulative exposure to 1,2-dichloropropane and incidence risk of cholangiocarcinoma among offset printing workers. | Kumagai, S., et al. 2016. Occup Environ Med. 73: 545-52. PMID: 273716621,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism. | Toyooka, T., et al. 2017. Toxicol Lett. 272: 60-67. PMID: 28300663Exposure of Mice to 1,2-Dichloropropane Induces CYP450-Dependent Proliferation and Apoptosis of Cholangiocytes. | Zhang, X., et al. 2018. Toxicol Sci. 162: 559-569. PMID: 29228347Acute inhalation co-exposure to 1,2-dichloropropane and dichloromethane cause liver damage by inhibiting mitochondrial respiration and defense ability in mice. | Wang, H., et al. 2019. J Appl Toxicol. 39: 260-270. PMID: 30240022Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages. | Zong, C., et al. 2019. Toxicol Sci. 168: 137-148. PMID: 30452740Reductive dechlorination of 1,2-dichloroethane in the presence of chloroethenes and 1,2-dichloropropane as co-contaminants. | Peng, P., et al. 2019. Appl Microbiol Biotechnol. 103: 6837-6849. PMID: 312500611,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis. | Jin, M., et al. 2019. Toxicol Res. 35: 361-369. PMID: 31636847Proteomic analysis of liver proteins of mice exposed to 1,2-dichloropropane. | Zhang, X., et al. 2020. Arch Toxicol. 94: 2691-2705. PMID: 324359161,2-Dichloropropane induces gamma -H2AX expression in human cholangiocytes only in the presence of macrophages. | Takizawa, R., et al. 2021. Toxicol Lett. 349: 134-144. PMID: 34153406Role of Macrophages in Cytotoxicity, Reactive Oxygen Species Production and DNA Damage in 1,2-Dichloropropane-Exposed Human Cholangiocytes In Vitro. | Ekuban, A., et al. 2021. Toxics. 9: PMID: 34205922Transcriptome analysis of human cholangiocytes exposed to carcinogenic 1,2-dichloropropane in the presence of macrophages in vitro. | Ekuban, A., et al. 2022. Sci Rep. 12: 11222. PMID: 35780190