Product Name :
2′-C-Methyladenosine (CAS 15397-12-3)
Synonym :
2′-Methyl-adenosine
Application :
2′-C-Methyladenosine is an inhibitor of HCV RNA replication
CAS:
15397-12-3
Purity:
≥98%
Molecular Weight:
281.27
Formula :
C11H15N5O4
Physical state:
Solid
solubility :
Soluble in DMSO, and DMF.
Shipping Condition :
Store at 4° C
Melting point:
>300° C (dec.)
SMILES:
C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C2N=CN=C3N)CO)O)O
References:
:Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs. | Carroll, SS., et al. 2003. J Biol Chem. 278: 11979-84. PMID: 12554735Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents.630108-94-0 Price | Yoo, BN.Price of 4-Chloropyrrolo[2,1-f][1,2,4]triazine , et al. 2006. Bioorg Med Chem Lett. 16: 4190-4. PMID: 16781148Liver-targeted prodrugs of 2′-C-methyladenosine for therapy of hepatitis C virus infection. | Hecker, SJ., et al. 2007. J Med Chem. 50: 3891-6. PMID: 17636948N6-Cycloalkyl- and N6-bicycloalkyl-C5′(C2′)-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice. | Franchetti, P., et al. 2009. J Med Chem. 52: 2393-406. PMID: 19317449Nucleoside inhibitors of tick-borne encephalitis virus. | Eyer, L., et al. 2015. Antimicrob Agents Chemother. 59: 5483-93. PMID: 26124166Targeting mitochondrial RNA polymerase in acute myeloid leukemia.PMID:33645443 | Bralha, FN., et al. 2015. Oncotarget. 6: 37216-28. PMID: 26484416Evaluation of antivirals against tick-borne encephalitis virus in organotypic brain slices of rat cerebellum. | Lenz, N., et al. 2018. PLoS One. 13: e0205294. PMID: 30300398An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice. | Eyer, L., et al. 2019. J Virol. 93: PMID: 31142664Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays. | Haviernik, J., et al. 2021. Antiviral Res. 185: 104968. PMID: 33157129Elimination of LRVs Elicits Different Responses in Leishmania spp. | Saura, A., et al. 2022. mSphere. 7: e0033522. PMID: 35943162Efficient elimination of RNA mycoviruses in aspergillus species using RdRp-inhibitors ribavirin and 2′-C-methylribonucleoside derivatives. | Ikeda, A., et al. 2022. Front Microbiol. 13: 1024933. PMID: 362747092′-C-methyladenosine and 2′-C-methyluridine 5′-diphosphates are mechanism-based inhibitors of ribonucleoside diphosphate reductase from Corynebacterium nephridii. | Ong, SP., et al. 1993. Biochemistry. 32: 11397-404. PMID: 8218205Mechanism-based inhibition of ribonucleoside diphosphate reductase from Corynebacterium nephridii by 2′-C-methyladenosine diphosphate. | McFarlan, SC., et al. 1996. Biochemistry. 35: 4485-91. PMID: 8605198