Product Name :
1,3-dichloropropan-2-ol (CAS 96-23-1)
Synonym :
Application :
CAS:
96-23-1
Purity:
Molecular Weight:
128.99
Formula :
C3H6Cl2O
Physical state:
Liquid
solubility :
Soluble in water, alcohol, diethyl ether, and acetone.
Shipping Condition :
Store at room temperature
Melting point:
-4° C (lit.)
SMILES:
C(C(CCl)O)Cl
References:
:Sensitive method for the determination of 1,3-dichloropropan-2-ol and 3-chloropropane-1,2-diol in soy sauce by capillary gas chromatography with mass spectrometric detection. | Chung, WC., et al. 2002. J Chromatogr A. 952: 185-92. PMID: 120645301,3-Dichloro-2-propanol induces apoptosis via both calcium and ROS in mouse melanoma cells. | Park, SY., et al. 2010. Biotechnol Lett. 32: 45-51. PMID: 19731046Toxicology, occurrence and risk characterisation of the chloropropanols in food: 2-monochloro-1,3-propanediol, 1,3-dichloro-2-propanol and 2,3-dichloro-1-propanol. | Andres, S., et al. 2013. Food Chem Toxicol. 58: 467-78. PMID: 237120971,3-Dichloro-2-propanol induced hyperlipidemia in C57BL/6J mice via AMPK signaling pathway.142356-33-0 SMILES | Lu, J., et al. 2014. Food Chem Toxicol. 64: 403-9. PMID: 243333981,3-Dichloro-2-propanol evokes inflammation and apoptosis in BV-2 microglia via MAPKs and NF- kappa B signaling pathways mediated by reactive oxygen species.12354-84-6 web | Xiao, C.PMID:33560694 , et al. 2018. Toxicol Lett. 284: 103-112. PMID: 29248572Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. | Lu, J., et al. 2018. Life Sci. 195: 19-24. PMID: 29305303Epigallocatechin-3-gallate protects against 1,3-dichloro-2-propanol-induced lipid accumulation in C57BL/6J mice. | Lu, J., et al. 2018. Life Sci. 209: 324-331. PMID: 300923001,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells. | Cheng, B., et al. 2018. Food Chem Toxicol. 122: 143-150. PMID: 30316840Caffeic acid abrogates 1,3-dichloro-2-propanol-induced hepatotoxicity by upregulating nuclear erythroid-related factor 2 and downregulating nuclear factor-kappa B. | Ajiboye, TO., et al. 2019. Hum Exp Toxicol. 38: 1092-1101. PMID: 311421311,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells. | Lu, J., et al. 2021. Toxicology. 454: 152716. PMID: 335812151,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice. | Fan, Y., et al. 2021. Food Chem Toxicol. 157: 112578. PMID: 34560177Diallyl disulfide prevents 1,3-dichloro-2-propanol-induced hepatotoxicity through mitogen-activated protein kinases signaling. | Kim, JW., et al. 2022. Food Chem Toxicol. 160: 112814. PMID: 349991781,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes. | Guan, S., et al. 2022. Environ Toxicol. 37: 2515-2528. PMID: 358701111,3-Dichloro-2-propanol-Induced Renal Tubular Cell Necroptosis through the ROS/RIPK3/MLKL Pathway. | Fan, Y., et al. 2022. J Agric Food Chem. 70: 10847-10857. PMID: 360005751,3-dichloro-2-propanol caused lipid droplets accumulation by suppressing neutral lipases via BMAL1 in hepatocytes. | Fan, Y., et al. 2023. Food Chem Toxicol. 174: 113670. PMID: 36805544